The klotho gene, which is named for the Greek Goddess Clotho who "spins the thread of life," has been connected with longevity and a variety of age-related conditions and diseases. This is the first time it has been shown to be a marker for accelerated cellular aging in humans.
The study involved 309 U.S. military veterans, of which a large percentage experienced PTSD, who had been deployed to the wars in Iraq and/or Afghanistan. All participants gave blood samples for genetic and metabolic analyses, and were evaluated for psychiatric conditions. They also underwent magnetic resonance imaging (MRI) to examine brain structure and function.
Researchers - Klotho - Genotype - PTSD - Symptoms
The researchers found that those with a particular klotho genotype who also had more severe PTSD symptoms were the ones who showed the strongest evidence of accelerated cellular aging. "We know that stress increases the likelihood of declining health. Our results suggest that klotho could be one factor that coordinates this decline across both the periphery and central nervous system, making...
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