Genetic clues to high rates of asthma in those of African ancestry

ScienceDaily | 2/20/2019 | Staff
bungienetbungienet (Posted by) Level 3
The study was published today in the journal Nature Communications.

Using advanced new technology, scientists were able to identify loci or locations on a specific chromosome that may put those of African descent at a higher risk of asthma.

Regions - Whites - Asians - Asthma - Areas

They also discovered four chromosomal regions usually found in whites and Asians associated with asthma. One of those chromosomal areas is known as the 17q12 -- 21 region.

Despite the high incidence of asthma among those of African ancestry, it has been historically underrepresented in genome-wide association studies (GWAS) even though the African genome is the most diverse on earth.

GWAS - Asthma - Ancestry - Populations - Date

"In the largest GWAS of asthma in African ancestry populations to date, we found strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, and we also identified two novel loci on chromosome 8 that may be specific to asthma risk in African ancestry populations," said the study's first author Michelle Daya, PhD, assistant professor in the division of Biomedical Informatics and Personalized Medicine at the CU School of Medicine.

According to Kathleen Barnes, PhD, the senior author on the study and director of the Colorado Center for Personalized Medicine at CU Anschutz, those of African ancestry in the Americas and elsewhere suffer a disproportionate burden of disability, disease and death from common chronic illnesses like asthma and diabetes.


Yet the group has been understudied.

To better understand this population and its genetic impact, Barnes worked with the National...
(Excerpt) Read more at: ScienceDaily
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