In a paper recently published in Advanced Materials, Angela Panoskaltsis-Mortari, PhD, Vice Chair for Research and Professor in the Department of Pediatrics at the University of Minnesota Medical School, Director of the 3D Bioprinting Facility and Member of the Masonic Cancer Center, and her fellow researchers found that cells behave differently in this 3D soft tissue environment than on 2D plastic or glass surfaces, for example.
"This model is more consistent with what the body is like," said Panoskaltsis-Mortari, "and, therefore, studying the effects of drugs with human cells at this level makes the results more meaningful and predictive of what will happen in the body."
Tumor - Tissues - Platform - Therapies - Anticancer
The 3D vascularized tumor tissues provide a platform to identify potential therapies and screen anticancer drugs. Importantly, this new model also provides a means to study metastatic cells -- cancer cells that have entered a blood vessel and traveled to another site.
"One of the reasons this model is successful is that we are better able to control the environment," said Fanben Meng, Post-Doctoral Associate in the College of Science and Engineering at the University of Minnesota. "We are able to slowly cause the release of the chemical mediators and create a chemical gradient. It gives the cells time...
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