Dr. qing li and a team of scientists recently completed a study investigating the compatibility of hydroxyapatite and collagen when used for 3D bioprinted scaffolds that serve as bone substitutes. 3D printing is the future of repairing bone trauma and defects because it can manipulate the biocompatible materials and live tissues into the organic geometries necessary to stimulate cellular bone growth; bone is porous and 3D printing can replicate that porosity. Li and the team of researchers worked with two types of hydroxyapatite (HA), a mineral that makes up most of the inorganic matter in tooth enamel and bones.
Function of the 3D-Bioplotter System as demonstrated at Rapid 2015. Credit: Mary Ann Liebert, Inc.
Nano - Hydroxyapatite - Bovine - Bone - DBB
Nano hydroxyapatite (nHA) and deproteinized bovine bone (DBB) were each mixed with collagen (CoL) to create two bio-inks for 3D printing with an EnvisionTEC 3D-Bioplotter, an advanced 3D bioprinter from Germany capable of low- and high-temperature bioprinting. They 3D printed a porous architecture that simulated cancellous bone (the spongy type of bone) with each formula and then ran them through a battery of materials characterization analyses, including X-ray photoelectron spectroscopy (XPS), X-ray powder diffraction (XRD), and Fourier Transform Infrared spectroscopy (FTIR). The use of scanning electron microscopy (SEM) revealed “different surface morphologies of the HA crystals...
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