Nanoparticle breakthrough in the fight against cancer

phys.org | 1/18/2019 | Staff
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A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has introduced a novel targeted drug delivery system in the fight against cancer.

A team of researchers, affiliated with UNIST has recently introduced a novel targeted drug delivery system that can improve the pharmacological and therapeutic properties of conventional cancer treatments. The new technology has dramatically enhanced safety and efficiency through the use of the supramolecularly built protein corona shield as a targeting agent through regulating the interfaces between nanoparticles and biological systems.

Breakthrough - Professor - Ja-Hyoung - Ryu - Professor

This breakthrough has been jointly led by Professor Ja-Hyoung Ryu, Professor Sebyung Kang, and Professor Chaekyu Kim in the School of Life Sciences at UNIST. Their findings have been published online in Nature Communications (IF: 12.353) on October 31, 2018.

Targeted drug delivery system refers to the method that selectively transports drugs to targeted tissues, organs, and cells through a variety of drugs carrier. Though tens of thousands of drug delivery systems have been developed, the effect has been minimal. This is because hundreds of proteins in the body stick to the drug delivery system (protein corona phenomenon). Because of this phenomenon, even when the drug reaches a target such as a cancer cell, the treatment efficiency is very low, and other side effects have been observed, which may cause toxic side effects.

Impact - Protein - Corona - Target - Drug

"It was reported that it is possible to alleviate the impact of protein corona on target drug delivery through the formation of protective shield, made up of well-structured special proteins that are highly stable and do not interact with each other," says Professor Ryu. "The new technology is much like the strategy where you take control of your enemies, using enemies."

In this work, the research team introduced the protein corona shield (PCS) concept for an efficient target drug delivery system....
(Excerpt) Read more at: phys.org
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