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An international team of researchers, affiliated with UNIST, has identified a novel route that regulates the signaling pathways induced by extracellular matrix (ECM). This may serve as a new diagnostic marker and therapeutic target in the fight against chronic liver diseases.
Led by Professor Jiyoung Park in the School of Life Sciences at UNIST, the research team has discovered that endotrophin (ETP) plays a crucial role in producing a pathological microenvironment in liver tissues of chronic liver disease. ETP is a marker of collagen type VI (COL6) formation, known as the link between obesity and cancer.
ETP - Levels - Tissues - Obesity - Diabetes
"ETP levels in adipose tissues are elevated in obesity or diabetes and are associated with adipose tissue fibrosis, inflammation, and angiogenesis, leading to metabolic dysfunction in adipose tissues and systemic insulin resistance," says Professor Park who first discovered ETP in 2012. "Through the identification of the correlation between ETP and chronic liver disease, this study opened new doors in the fight against liver diseases."
The study reveals ETP plays an important role in the interaction between 'hepatocytes' and 'non-parenchymal cells' in the progression of liver disease, as follows: ① the signaling pathways from ETP kills the hepatocytes, ②...
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