Abnormal brain development in adolescence is associated with adult mental illness. Researchers from the University of Warwick have discovered how genes that are directly associated with mental illness become pathogenic.
Feng Jianfeng's research team, from the Department of Computer Science, have analyzed over 10,000 genetic imaging data collected from more than 20 universities in 6 countries.
Association - Study - Mutation - Risk - Schizophrenia
By whole-brain and whole-genome association study, they have found that a genetic mutation -- that was associated with higher risk for schizophrenia, was significantly correlated to the enlargement of putamen volume in adolescent brains.
The study has found a new pathway of genetic risk disrupting the development of adolescent brain and thereby further increasing the risk of mental illness, which will hopefully help reveal the pathogenesis of schizophrenia and provide new possibilities for the theoretical study of prior intervention before the emergence of clinical symptoms.
Prevention - Treatment - Disorders - Challenges - Illness
Prevention and treatment of psychiatric disorders are global challenges. It is reported that mental illness has become one of the biggest challenges of the medical system, exceeding that of cardiovascular and cerebrovascular diseases and malignant tumor.
The clinical symptoms of various mental diseases may be caused by abnormal brain development in adolescence. However, previous study has accumulated 20,000 genetic imaging data worldwide had failed to identify any genetic variant that is associated with both higher risk for psychiatric disorders and grey matter volume of brain structure.
Team - Brain - Images - Adolescents - Atlas
The team focused on brain structural images of 14-year-old healthy adolescents. Instead of applying the classic anatomical atlas of brain regions, the current research had chosen to run a holistic exploratory analysis at a voxel-wise and genome-wide level, and found for the first time that grey matter volume...
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