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This breakthrough has been jointly led by Professor Ja-Hyoung Ryu, Professor Sebyung Kang, and Professor Chaekyu Kim in the School of Life Sciences at UNIST. Their findings have been published online in Nature Communications (IF: 12.353) on October 31, 2018.
Targeted drug delivery system refers to the method that selectively transports drugs to targeted tissues, organs, and cells through a variety of drugs carrier. Though tens of thousands of drug delivery systems have been developed, the effect has been minimal. This is because hundreds of proteins in the body stick to the drug delivery system (protein corona phenomenon). Because of this phenomenon, even when the drug reaches a target such as a cancer cell, the treatment efficiency is very low, and other side effects have been observed, which may cause toxic side effects.
Impact - Protein - Corona - Target - Drug
"It was reported that it is possible to alleviate the impact of protein corona on target drug delivery through the formation of protective shield, made up of well-structured special proteins that are highly stable and do not interact with each other," says Professor Ryu. "The new technology is much like the strategy where you take control of your enemies, using enemies."
In this work, the research team introduced the protein corona shield (PCS) concept for an efficient target drug delivery system. Using recombinant DNA technology, the research team has created recombinant fusion proteins with the enhanced physical stability and cancer-selective targeting ability. This fusion protein, then, was used as a shield to...
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