"One good thing about fever is that it can promote lymphocyte trafficking to the site of infection, so you will have more immune cells in the infected region that will get rid of the pathogen," says Shanghai Institute of Biochemistry and Cell Biology (SIBCB) Professor and senior author JianFeng Chen.
To get to an infection, white blood cells need to adhere to the blood vessel and then transmigrate into the infected tissue or lymph node. During this step, molecules known as integrins are expressed on the surface of lymphocytes. Integrins are cell adhesion molecules that control lymphocyte trafficking during inflammation.
Chen - Colleagues - Fever - Expression - Heat
Chen and colleagues discovered that fever increases the expression of heat shock protein 90 (Hsp 90) in T lymphocytes. This protein binds to a type of integrin on the lymphocytes -- α4 integrins -- which promote lymphocyte adhesion to the blood vessel and ultimately to expedited migration to the site of infection.
The researchers learned that fever-induced Hsp90 binds to the integrin tail and induces integrin activation. Moreover, one Hsp90 can bind to two integrins leading to a clustering of integrins on the lymphocyte surface. As a result, the clustered integrins...
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