Guidelines for the therapeutic use of melatonin

ScienceDaily | 12/11/2018 | Staff
This is the view expressed by José Cipolla Neto, Full Professor at the University of São Paulo's Biomedical Science Institute (ICB-USP), and Fernanda Gaspar do Amaral, a professor at the Federal University of São Paulo (UNIFESP), both in Brazil, in an article published in the journal Endocrine Reviews.

Cipolla Neto is the principal investigator for a project supported by São Paulo Research Foundation -- FAPESP on the role of melatonin in energy metabolism regulation.

Melatonin - Organism - Rest - Day - Food

"Melatonin not only adapts the organism to nocturnal rest but also prepares it metabolically for the next day, when it will need to be sufficiently sensitive to absorb food, for example," he said. The body produces melatonin only at night.

"If the nocturnal production of melatonin is blocked by light during the night, especially by the blue light from smartphones, this can contribute to diseases, such as sleep disorders and hypertension, and metabolic disturbances, including obesity and diabetes. This potentially pathogenic situation is due not only to insufficient melatonin production but also to one of its more immediate consequences, which is a condition known as chronodisruption, a temporal disorganization of the circadian rhythm of biological functions," Cipolla Neto told.

Present - Beings - Bacteria - Humans - Melatonin

Present in almost all living beings, from bacteria to humans, melatonin has been the focus of many clinical studies. In the last five years alone, more than 4,000 studies using melatonin have been published. Almost 200 of those were randomized clinical trials.

Between 1996 and July 2017, for example, 195 systematic reviews were published on the effects of the clinical use of melatonin, among which 96 addressed the use of melatonin to treat psychiatric diseases and neurological disturbances, including sleep disorders, while 43 focused on the association between melatonin and cancer.

Patent - Applications - Uses - Melatonin - Analogs

Patent applications relating to therapeutic uses of melatonin and analogs filed worldwide between 2012 and September 2014 focused predominantly on the central...
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