Cellular gene signatures for heart muscle regeneration

ScienceDaily | 11/30/2018 | Staff
Researchers believe that human-induced pluripotent stem cells (hiPSC) are the key to unlocking this regenerative ability. By taking a tiny bit of blood, scientists can generate an individual's patient specific stem cells and then convert them into any cell type in the body -- including cardiomyocytes, the cells that make up the heart muscle. The research, however, is in its infancy and the technique is not yet ready to be deployed for human heart disease regenerative purposes.

Now, researchers at the University of Arizona are one step closer to understanding hiPSC cardiomyocytes and how they may better be utilized to repair heart muscles. In a study published this month in Nature Communications, Jared Churko, PhD, assistant professor of Cellular and Molecular Medicine at the UA College of Medicine -- Tucson, used a systems-based approach encompassing single-cell transcriptomics, single-cell proteomics and CRISPR gene-editing to identify different subpopulations of cardiomyocytes.

Definitions

Definitions:

Transcriptomics is the study of the transcriptome -- quantification of the types of RNA produced within the cell.

Proteomics - Study - Proteomes - Proteins - Cell

Proteomics is the study of proteomes, the proteins expressed by a cell, tissue or organism.

CRISPR gene editing is a technology for modifying an organism's DNA code at the single-cell level. This...
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