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Researchers at Vanderbilt University Medical Center and colleagues have isolated a human monoclonal antibody that can "neutralize" the West Nile virus and potentially prevent a leading cause of viral encephalitis (brain inflammation) in the United States.
Their findings, reported this week in the journal Nature Microbiology, could lead to the first effective treatment for this mosquito-transmitted infection, which sickens 2,500 and kills more than 100 people throughout the country each year, according to the U.S. Centers for Disease Control and Protection (CDC).
Virus - Cause - Brain - Infections - US
"West Nile virus is still an important cause of brain infections in the U.S., and there is very little we can do to help these patients," said James Crowe Jr., MD, co-corresponding author of the paper and director of the Vanderbilt Vaccine Center.
"It was exciting for us to use our antibody discovery technologies to find naturally occurring human antibodies that can prevent or treat the infection," he said.
Crowe - Ann - Scott - Carell - Chair
Crowe holds the Ann Scott Carell Chair in the Departments of Pediatrics and Pathology, Microbiology &...
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