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A chemical compound found in common herbicides could help fight hospital-acquired human fungal pathogenic infections, which claim an estimated two million lives per year.
A team of international researchers led by The University of Queensland has discovered that the chemical chlorimuron ethyl also targets a range of fungal infections that are potentially fatal to humans, particularly people undergoing treatments which place the immune system under stress.
Dr - Luke - Guddat - UQ - School
Dr. Luke Guddat, from UQ's School of Chemistry and Molecular Biosciences, said the finding was very timely, given the growth in drug-resistant infections.
"There are more drug-resistant fungal diseases than ever – posing a major threat to global human health – and new drugs are urgently required to combat these diseases," he said.
Research - Class - Herbicide - Ability - Growth
"Through this research we wanted to see if a specific class of commercial herbicide has the ability to stop the growth of these infections.
"We thought this was a good idea, since plants and fungi have a similar enzyme that these chemicals inhibit, and it turns out we were correct."
Researchers - Families - Compounds - Enzyme - Species
The researchers tested five different families of compounds, to see if they could inhibit a key enzyme from the fungal species, Candida albicans...
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