Mechanisms of hair follicle-specific fibroblast formation unraveled

phys.org | 8/23/2018 | Staff
entengo (Posted by) Level 3
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Hair growth is regulated by a small cluster of hair-specific fibroblasts, the dermal papilla. But exactly how the dermal papilla forms has remained elusive until now. In a recent study, professor Marja Mikkola's research group at the University of Helsinki used confocal microscopy of live skin to show that the dermal condensate forms via cell migration.

In a study recently published in eLife, Leah Biggs and Otto Mäkelä and their co-workers from the Institute of Biotechnology, University of Helsinki investigated the cellular and molecular mechanisms driving dermal condensate formation. The research group of Marja Mikkola used confocal microscopy of live skin to show that the dermal condensate forms via cell migration. Further, they discovered that dermal condensate cells cease proliferation soon after commitment.

Papilla - Cells - Vitro - Graduate - Student

"This might explain why it has been so difficult to expand dermal papilla cells in vitro," says graduate student Otto Mäkelä.

Hair growth is regulated by a small cluster of cells known as the dermal papilla. This dermal papilla only arises once during the lifetime of an organism and is lost upon skin injury. Further, upon transplantation, the dermal...
(Excerpt) Read more at: phys.org
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