The mechanisms of genetic diversification in Candida albicans

phys.org | 7/10/2018 | Staff
smnth28 (Posted by) Level 3
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Candida albicans. Credit: Wikipedia.

Candida albicans is one of the most formidable fungal species infecting humans. Investigating the structure and reproduction methods of pathogenic populations can reveal how they emerge and spread. A team of scientists has sequenced and analyzed the genomes of 182 strains of C. albicans from around the world. They confirmed the clonal reproduction of this C. albicans, and also showed that parasexual reproduction, previously only observed in a laboratory setting, contributes to its genetic diversity, and therefore also to its ability to adapt to new environments and rid itself of deleterious mutations.

Species - Disease - Humans - Candida - Species

There are 5 million fungal species, but only a few hundred can cause disease in humans. Candida albicans is one of the most formidable of these species. It belongs to one of the four genera of pathogenic fungi responsible for high mortality rates in humans and is the second most common agent of opportunistic fungal infection in the world. Candida albicans is part of the human gut microbiota (a commensal fungus) but it also causes mucosal infections in healthy individuals and severe opportunistic infections in those with weakened immune defenses (immunocompromised individuals and patients who have received organ transplants, undergone serious surgery or suffered major trauma).

Understanding how pathogens emerge and spread involves analyzing the structure of their populations. Several studies have shown the importance of population genetics in shedding light on the emergence of new diseases, such as white-nose syndrome...
(Excerpt) Read more at: phys.org
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