Approaching an ideal amino acid synthesis using hydrogen

phys.org | 6/11/2018 | Staff
kims (Posted by) Level 3
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Osaka University researchers demonstrated a reductive alkylation method for the functionalization of substituted amines using hydrogen, which is efficiently catalyzed by innocuous main-group catalysts. Their reaction generated water as the sole byproduct. The presented reaction is highly versatile and environmentally benign, and therefore expected to be applied to wide areas of chemical synthesis. These benefits will contribute to establishment of a high throughput screening of potential drug candidates.

Amines are an essential part of our everyday lives; a fact supported by the number of bioactive molecules, including natural products, pharmaceuticals, and agrochemicals that contain amine motifs. Therefore, the development of green, sustainable, and waste-minimized approaches for the synthesis of amines and amino acids, using readily available catalysts and less toxic reagents, remains a significant challenge.

Group - Researchers - Osaka - University - Method

A group of researchers from Osaka University has now developed a practical and environmentally innocuous method for the functionalization of multiply substituted amines. Their results were published in the Journal of the American Chemical Society.

"Amines are present in many bioactive molecules, so being able to functionalize them using a benign catalyst and hydrogen is an attractive approach that will allow researchers to realize challenging molecular transformations," Sensuke Ogoshi, one of...
(Excerpt) Read more at: phys.org
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