Mechanisms of harmful overhydration and brain swelling

ScienceDaily | 5/22/2018 | Staff
emilia (Posted by) Level 3
"[Hyponatremia] occurs in common pathological conditions, including brain injury, sepsis, cardiac failure and in the use of drugs, such as MDMA (ecstasy)," says Dr. Charles Bourque, whose team from the Centre for Research in Neuroscience at the Research Institute of the McGill University Health Centre (RI-MUHC) uncovered a key piece to the puzzle of how our brains detect hyponatremia and regulate overhydration. The new study featured in Cell Reports unearths the fundamental mechanism of how hyponatremia is detected in the brain.

"Our specific data will be important for people studying hydromineral and fluid electrolyte homeostasis, and clinicians who treat patients faced with hyponatremia," reports Dr. Bourque, who is a scientist in the Brain Repair and Integrative Neuroscience Program (BRAIN) at the RI-MUHC and a professor in McGill's Department of Neurology. This condition is more common in elderly patients and can cause cognitive problems and seizures in this vulnerable group. While it remains uncertain how hyponatremia develops, a defect in the hydration sensing mechanism of the brain could be the culprit.

Strangers - Mechanisms - Hydration - Body - Dr

No strangers to studying the mechanisms of hydration in the body, Dr. Bourque's team, located at the Montreal General Hospital, has also made several key discoveries in the past on how the brain detects and prevents dehydration; how salt intake increases blood pressure; and how the brain's biological clock stimulates thirst prior to sleep. In this instance, experiments by Sorana Ciura, a PhD student in Dr. Bourque's laboratory, who is now...
(Excerpt) Read more at: ScienceDaily
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