A research team led by Dr. Richard Wang, Assistant Professor of Dermatology, demonstrated in mice that inhibiting glucose transport may be a safe and effective treatment for these diseases. Actively dividing cells, like those underlying psoriasis, are more dependent on glucose for their growth. By inhibiting glucose transport in those cells, disease-associated skin overgrowth and inflammation were reduced. Their findings were recently published in Nature Medicine.
"This study provides a window for the treatment of various diseases by specifically targeting the metabolic requirements of hyperproliferative skin diseases. It also broadens our understanding of changes in skin metabolism in response to physiological stressors," Dr. Wang said.
Psoriasis - Therapies - Immune - Cells - Disease
Most psoriasis therapies inhibit the immune cells that underlie the disease. They have been limited somewhat by side effects caused by broadly targeting the immune system, he said.
The study results, if proved effective in humans, may lead to development of new treatments for those with incurable skin conditions like psoriasis, a chronic autoimmune disease that affects more than 7 million people in the U.S., according to the Centers for Disease Control and Prevention. The condition manifests as patches of red skin with silvery scales typically found on the elbows, knees, scalp, lower back, face, palms, and soles of feet.
Studies - People
Recent studies have shown that people with...
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