Antibiotics: New substances break bacterial resistance

phys.org | 5/24/2018 | Staff
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Researchers at the Martin Luther University Halle-Wittenberg (MLU) have developed a promising new class of active ingredients against resistant bacteria. In initial tests in cell cultures and insects, the substances were at least as effective as common antibiotics. The new compounds target a special enzyme that only appears in bacteria in this specific form and that was not previously the target of other antibiotics. This is why bacteria have not yet developed any resistance to it. The team reported on its work in the journal Antibiotics.

Resistant bacteria including staphylococcus and the dreaded MRSA germs are a problem for physicians and patients worldwide. Recently, several large pharmaceutical companies announced that they were cutting back on research work into new antibiotics. "However, in order to be able to treat infectious diseases reliably and in the long run, we need new, active substances against which bacteria have not yet developed resistances," says Professor Andreas Hilgeroth from the Institute of Pharmacy at MLU. Together with researchers from the University of Greifswald and the Julius Maximilian University of Würzburg, he is working on these new active substances in a research project funded by the Federal Ministry of Education and Research.

Scientists

The scientists have developed...
(Excerpt) Read more at: phys.org
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