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Researchers in Asia used triple-coaxial cell printing technology to construct biomimetic tissue-engineered blood vessels that include an endothelium layer surrounded by a smooth muscle layer. The prematured blood vessels were evaluated in vivo through an interpositional abdominal aorta graft in a rat model. Credit: Gao et al.
A biomimetic blood vessel was fabricated using a modified 3-D cell printing technique and bioinks, which were formulated from smooth muscle cells from a human aorta and endothelial cells from an umbilical vein. The result is a fully functional blood vessel with a dual-layer architecture that outperforms existing engineered tissue and brings 3-D-printed blood vessels several fundamental steps closer to clinical use.
Blood - Vessels - Aortas - Rats - Weeks
The engineered blood vessels were grafted as abdominal aortas into six rats. Over the next several weeks, scientists observed a transformation in which the rat's fibroblasts formed a layer of connective tissue on the surface of the implant to integrate the fabricated vessel graft as part of the existing, living tissue. The results, published in Applied Physics Reviews, include details on the triple-coaxial 3-D printing technology they developed and their analysis of the unique architecture, physical strengths and biological activity of the engineered tissue.
"The artificial blood vessel is an essential tool to save patients suffering from cardiovascular disease," author Ge Gao...
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